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Using the body's own cells to treat traumatic brain injury

Shining a light on the hidden damage of mild

<p>We all know someone who&#39;s had a head injury that was &quot;only&quot; a concussion, but even mild traumatic brain injuries can cause lasting damage, and the vast majority are never diagnosed. A team led by Samir Mitragotri at the Wyss Institute, Harvard SEAS, and Boston Children&#39;s Hospital&nbsp;created a way to diagnose mild TBIs (mTBIs) even when MRI scans showed nothing, using the body&#39;s own immune cells called macrophages. They attached microparticle &quot;backpacks&quot; containing a common MRI contrast agent to the cells, which migrated to the brain and allowed them to see evidence of inflammation in pigs with a mock mTBI.</p>

New approach leverages macrophages to treat traumatic brain injury

Scientists have created a new treatment for traumatic brain injury (TBI) that shrank brain lesions by 56% and significantly reduced local inflammation levels in pigs.

Using the body's own cells to treat traumatic

<p>Traumatic brain injuries (TBIs) can cause lasting damage, but stopping the rampant brain inflammation they cause is difficult. A team at the Wyss, @SEAS and @MGH led by Samir Mitragotri has made a new treatment using macrophages - immune cells that migrate to the brain. By attaching microparticle &quot;backpacks&quot; that kept the macrophages in a healing state, they reduced the size of brain lesions by 56% in pigs with a mock TBI.</p>

Shining a light on the hidden damage of mild brain injuries

Using the body's own cells to treat traumatic brain injury

Illuminating Hidden Harm of Mild Brain Injuries

Shining a light on the hidden damage of mild

<p>We all know someone who&#39;s had a head injury that was &quot;only&quot; a concussion, but even mild traumatic brain injuries can cause lasting damage, and the vast majority are never diagnosed. A team led by Samir Mitragotri at the Wyss Institute, Harvard SEAS, and Boston Children&#39;s Hospital&nbsp;created a way to diagnose mild TBIs (mTBIs) even when MRI scans showed nothing, using the body&#39;s own immune cells called macrophages. They attached microparticle &quot;backpacks&quot; containing a common MRI contrast agent to the cells, which migrated to the brain and allowed them to see evidence of inflammation in pigs with a mock mTBI.</p>

Treating Traumatic Brain Injury with Body's Own Cells