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CCR4 Antagonists May Bolster Immune Responses With Checkpoint Inhibitors in PD-L1+ NSCLC

The addition of tivumecirnon to pembrolizumab was safe, well-tolerated, and clinically active vs the historical activity of pembrolizumab monotherapy in patients with checkpoint inhibitor–naive non–small cell lung cancer.
United States Johns Hopkins University Roberta Anders Johns Hopkins Kimmel Cancer Center Johns Hopkins University School Of Medicine Johns Hopkins University School

Dr Anders on the Rationale For Investigating Tivumecirnon Plus Pembrolizumab in NSCLC

Robert A. Anders, MD, PhD, discusses the rationale for investigating the use of tivumecirnon in patients with non–small cell lung cancer, as well as interim data from the dose-expansion portion of the phase 1/2 FLX475-02 study of this agent alone and in combination with pembrolizumab.
Roberta Anders Johns Hopkins University School Of Medicine Johns Hopkins Sidney Kimmel Cancer Center Johns Hopkins University School Patients With Non Small Cell Lung Cancer Trop 2 Adcs

New pathologic scoring system could help predict survival in lung cancer patients

A new pathologic scoring system that accurately assesses how much lung tumor is left after a patient receives presurgical cancer treatments can be used to predict survival, according to new research led by investigators at the Bloomberg~Kimmel Institute for Cancer Immunotherapy at the Johns Hopkins Kimmel Cancer Center and the Mark Foundation Center for Advanced Genomics and Imaging at the Johns Hopkins University.
United Kingdom San Diego United States France General New Jersey Johns Hopkins

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Inhibitor Drug Entinostat 'Primes' the Body to Better Respond to Anti-Cancer Treatment with Immunotherapy – India Education | Latest Education News | Global Educational News

Combining a histone deacetylase inhibitor drug with immunotherapy agents is safe, and may benefit some patients with advanced cancers that have not responded to traditional therapy, according to results of a phase 1 clinical trial led by researchers
United States University Of Southern California Molly Geare David Lim Elizabethm Jaffee Chenguang Wang

Astronomy meets pathology to identify predictive biomarkers for cancer immunotherapy

 E-Mail IMAGE: The AstroPath platform allows for the assessment of the level of expression of a given marker on individual cells, while maintaining information on their spatial location. Shown here is... view more  Credit: Seyoun Park, Ph.D. Pairing sky-mapping algorithms with advanced immunofluorescence imaging of cancer biopsies, researchers at The Mark Foundation Center for Advanced Genomics and Imaging at Johns Hopkins University and the Bloomberg~Kimmel Institute for Cancer Immu...
United States Janis Taube Charles Roberts Evanj Lipson Richard Wilton Shlomit Jessel

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