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Tracking immune correlates of protection for emerging SARS-CoV-2 variants

Reliable SARS-CoV-2 correlates of protection (COP) are crucial for predicting individual-level risk of infection, estimating population susceptibility, and assessing future epidemic risks.1 However, COP studies are challenging given that blood samples ideally need to be collected close to the time of exposure, which is hard to predict. Thus, most existing SARS-CoV-2 COP estimates are based on vaccine efficacy trial data,2,3 which include frequent blood sampling and strict infection monitoring an...
United States United Kingdom Dominican Republic Ministry Of Health Us Centers For Disease Lancet Reg Health

Application of a sex-specific GRACE score in practice – Authors' reply

We thank Dorien M Kimenai and Nicholas L Mills for their interest in our Article.1 Indeed, sex-specific diagnostic thresholds of troponin were introduced into the Universal Definition of Myocardial Infarction in 2012 during the recruitment period of our study and have led to increased diagnostic sensitivity in the decade since.2
United States United Kingdom Northern Ireland Daiichi Sankyo Dorienm Kimenai Boehringer Ingelheim

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Phylogenetic evidence for a clade of tick-associated trypanosomes | Parasites & Vectors

Trypanosomes are protozoan parasites of vertebrates that are of medical and veterinary concern. A variety of blood-feeding invertebrates have been identified as vectors, but the role of ticks in trypanosome transmission remains unclear. In this study, we undertook extensive molecular screening for the presence and genetic diversity of trypanosomes in field ticks. Examination of 1089 specimens belonging to 28 tick species from Europe and South America led to the identification of two new trypanos...
French Guiana Tissue Kit Thermo Scientific Roche Diagnostics Eurofins Genomics Chromas Lite

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