The expansion includes an investment for offices at Russell Business Centre, opposite Belfast City Hospital.
Some 20 positions have already been filled, including two management roles.
The investment marks the private nursing and care provider s expansion from its headquarters in Dundrum.
T-Gem Healthcare champions independence at home and supports whose who need to stay in their own homes rather than going into care accommodation.
The company provides a range of services from 30-minute visits to full time live-in care.
The former helps with personal care, cleaning, shopping and gardening, while the latter supports people with illnesses such as multiple sclerosis, motor neurone disease, Parkinson s, Alzheimer s and dementia.