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Why some melanoma patients do not respond to immunotherapy

 E-Mail NEW YORK, NY (March 1, 2021)--By harnessing the immune system against cancer, immunotherapies have revolutionized the way some types of cancer are treated. But most patients--across cancer types--do not respond, and in most cases, scientists are at a loss as to why. Researchers at Columbia and MIT have created a new technique that can uncover nearly all of the tricks cancer cells use to evade immunotherapies, which could lead to the development of more effective treatments. The researc...
Adriennem Luoma Dana Farber Chantale Bernatchez Dirk Schadendorf Benjamin Izar Shruti Malu Dana Farber Pratikshai Thakore

New screening platform leads to discovery of next-generation prodrugs for type 1 diabetes

 E-Mail With nearly 2 million Americans battling type 1 diabetes, it is no surprise that clinical therapies for the disease are constantly evolving and improving. In type 1 diabetes mellitus, the bodys immune system attacks and destroys insulin-producing β-cells. As a result, people living with type 1 diabetes lose insulin secretion and encounter difficulty regulating glucose levels -- especially after meals. Drugs developed to proliferate β-cells often are inefficient and have off-target ef...
United States Peter Jones Amit Choudhary Jeff Karp Kisuk Yang Brigham Department Of Anesthesiology

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