Pain Crises in Sickle Cell Disease: A Clinical Guide to Prevention and Treatment
Defining Sickle Cell Disease Sickle cell disease (SCD) is the consequence of homozygosity for a single amino acid change in the beta-globin chain that results in structurally abnormal hemoglobin S, or by compound heterozygosity for hemoglobin S and another β-globin chain abnormality, typically hemoglobin C or beta-0 thalassemia. Hemoglobin SS (HbSS) and HbS beta-0 thalassemia present in a similar clinical manner and are commonly referred to together as sickle cell anemia (SCA), which is the m...
United States Voxelotor Oxbryta National Acute Chest Syndrome Study Group World Health Organization American Society Of Hematology Centers For Medicare
Source: practicalpainmanagement.com