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How Huntington's Disease Affects Different Neurons

Researchers have identified how two different populations of neurons in the striatum are affected differently in Huntington's disease. The neurodegeneration of one of these populations leads to motor defects while damage to the other population located in striosomes may account for mood disorders associated with the early stages of Huntington's.
Ann Graybiel Myriam Heiman Richard Faull Sarah Mcdonnell Jessicaj Pourian Manolis Kellis

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How Huntington's disease affects different neurons | MIT News | Massachusetts Institute of Technology

MIT neuroscientists find two distinct cell populations in the striatum are affected differently by Huntington’s disease. They believe neurodegeneration of one of these populations leads to motor impairments, while damage to the other population, located in a structure called the striosome, may account for the mood disorders that are often see in the early stages of the disease.
Ann Graybiel Myriam Heiman Richard Faull Jessicaj Pourian Manolis Kellis Robert Buxton
Source: mit.edu

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