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The mutations occur spontaneously in noncoding stretches of DNA that control gene expression.

Siblings of autistic females are more likely to have autism than siblings of autistic males are, and mothers of autistic children carry more common, autism-linked variants than fathers do.

A fruit fly study has uncovered the functional significance of gene mutations associated with autism.

About 1 in 44 children in the U.S. are diagnosed with autism spectrum disorder (ASD) by the age of 8, according to the 2018 Centers for Disease Control and Prevention surveillance. How a child's DNA contributes to the development of ASD has been more of a mystery.

By Brita Belli April 16, 2021 Share this with FacebookShare this with TwitterShare this with LinkedInShare this with EmailPrint this (© stock.adobe.com) It is well established that autism occurs much more frequently in boys than in girls, and that girls seem to have a greater resilience to developing the condition. It has been unclear, however, why that is. In a new Yale-led study, researchers find that autism may develop in different regions of the brain in girls than boys and that girls with...

Date Time Researchers find clues to sex differences in autism It is well established that autism occurs much more frequently in boys than in girls, and that girls seem to have a greater resilience to developing the condition. It has been unclear, however, why that is. In a new Yale-led study, researchers find that autism may develop in different regions of the brain in girls than boys and that girls with autism have a larger number of genetic mutations than boys, suggesting that they require a ...

Studies Indicate How Mosaic Mutations Contribute to Autism Risk January 13, 2021 Two studies published in Nature Neuroscience implicate mosaic mutations arising during embryonic development as a cause of autism spectrum disorder (ASD). The investigations, led by researchers at Boston Children’s Hospital, Brigham and Women’s Hospital (BWH), and Harvard Medical School (HMS), point to new areas for exploring the genetics of ASD and could eventually inform diagnostic testing. The two reported...

Two studies in todays Nature Neuroscience, led by researchers at Boston Childrens Hospital, Brigham and Womens Hospital (BWH), and Harvard Medical School (HMS), implicate mosaic mutations arising during embryonic development as a cause of autism spectrum disorder (ASD). The findings open new areas for exploring the genetics of ASD and could eventually inform diagnostic testing. Mosaic mutations affect only a portion of a persons cells. Rather than being inherited, they arise as a "mistake" int...