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BASECAMP-1 Trial Aims to Identify Patients With Solid Tumors Who Are Eligible for A2B530

The observational BASECAMP-1 screening study has started to identify patients with advanced solid tumors harboring somatic human leukocyte antigen-A*02 loss of heterozygosity who would be eligible to receive the novel Tmod CAR T-cell therapy, A2B530, if their cancer relapses after standard of care treatment.
United States San Diego Diane Simeone Maria Pia Morelli Isaac Perlmutter Grossman School Of Medicine

"Efficacy and safety of cosibelimab, an anti-PD-L1 antibody, in metasta" by Philip Clingan, Rahul Ladwa et al.

BACKGROUND: Programmed cell death receptor-1 (PD-1)-blocking antibodies are approved to treat metastatic or locally advanced cutaneous squamous cell carcinoma (CSCC) cases ineligible for curative surgery or radiation. Notwithstanding, some patients experience inadequate responses or severe immune-related adverse events (AEs), indicating the need for improved therapies. Cosibelimab is a high-affinity programmed cell death-ligand 1 (PD-L1)-blocking antibody that activates innate and adaptive immun...
Response Evaluation Criteria Solid Tumors Immune Checkpoint Inhibitors Rogrammed Cell Death 1 Receptor Kin Neoplasms
Source: uow.edu.au

U.S. Food and Drug Administration Approves Augtyro™ (repotrectinib), a Next-Generation Tyrosine Kinase Inhibitor (TKI), for the Treatment of Locally Advanced or Metastatic ROS1-Positive Non-Small Cell Lung Cancer (NSCLC)

The approval is based on the pivotal TRIDENT-1 trial, in which Augtyro successfully achieved a high objective response rate and durable response1 Augtyro adds to Bristol Myers Squibb’s growing...
United States Janet Freeman Samit Hirawat Jessicaj Lin Bristol Myers Squibb Drug Administration

87.5% ORR | Abbisko presented two clinical updates of Pimicotinib at the 2023 CTOS Annual Meeting

SHANGHAI, Nov. 6, 2023 /PRNewswire/ -- Abbisko Therapeutics Co., Ltd. (Abbisko Therapeutics hereafter) announced that two major clinical updates...
United States Data Monitoring Committee European Medicines Agency Connective Tissue Oncology Society Annual Meeting Prnewswire Abbisko Therapeutics Co Ltd Tissue Oncology Society Annual Meeting

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