Spider-Man: Does Uncle Ben exist in the MCU?
Most iterations of Peter Parker’s origin story contain two vital points: he gets bitten by a radioactive spider, and his uncle, Ben Parker, dies. Bruce Wayne sees his mother’s pearls hitting the pavement, Kal-El gets shot off of Krypton on a spaceship, Peter Parker loses Uncle Ben. Peter's dear Aunt May fills the void. That's simply the way it works in classic comic book stories.
Source: syfy.com