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Enhancer-gene mapping with SCENT method offers insights into disease mechanisms

Genetic studies of diseases map segments of the genome driving disease. But to understand how those changes contribute to disease progression, it is important to understand how they may alter gene regulation of disease genes in cell populations assumed to be driving disease.

Soumya raychaudhuriBrigham division of rheumatologyMass general brigham

Researchers develop statistical method for genetic mapping of autoimmune diseases

Researchers develop statistical method for genetic mapping of autoimmune diseases
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Soumya raychaudhuriSaori sakaueBrigham division of rheumatologyNature geneticsMass general brigham

Study sheds new light on the variety of cellular causes of rheumatoid arthritis

Rheumatoid arthritis (RA) is an autoimmune disease characterized by inflammation that leads to pain, joint damage, and disability, which affects approximately 18 million people worldwide.

Soumya raychaudhuriDanielle ellisMichael brennerBrigham division of rheumatologyMedicines partnership rheumatoid arthritisBroad instituteMass general brighamSystemic lupus erythematosusPrecision medicineRheumatoid arthritisAutoimmune disease

Cellular atlas built to guide precision medicine treatment of rheumatoid arthritis

Cellular atlas built to guide precision medicine treatment of rheumatoid arthritis
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Soumya raychaudhuriMichael brennerBroad instituteMedicines partnership rheumatoid arthritisBrigham division of rheumatologyMass general brighamSystemic lupus erythematosus

Cellular Atlas Developed for Precision Rheumatoid Arthritis Care

Cellular Atlas Developed for Precision Rheumatoid Arthritis Care
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United statesKathryn weinandGary firesteinMark mayburyZhihan liDana weisenfeldIlya korsunksyAdam chicoineKamil slowikowskiAndrew filerSoumya raychaudhuriGregory kerasDeepak raoNida meednuYakir reshefSusan goodman