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And get tested regularly. you must be hiv-negative to take descovy for prep. so, you need to get tested for hiv immediately before and at least every 3 months while taking it. if you think you were exposed to hiv or have flu-like symptoms, tell your doctor right away. they may check to confirm you are still hiv-negative. serious side effects can occur, including kidney problems and kidney failure. rare, life-threatening side effects include a build-up of lactic acid and liver problems. the most ...