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The major finding of the study, Herpes Simplex Virus 1 (HSV-1) 0ΔNLS Live-Attenuated Vaccine Protects against Ocular HSV-1 Infection in the Absence of Neutralizing Antibody in HSV-1 gB T Cell Receptor-Specific Transgenic Mice, found that the company s RVX101 vaccine candidate used to immunize a unique mouse line (does not generate much of a neutralizing antibody response to the virus) was shown to provide highly protective immunity and prevent herpes-associated neovascularization. This robust efficacy was found to be correlated with CD8+ T cells, since depleting these cells after vaccination, but before challenge with HSV-1 eliminated any efficacy realized by the vaccine.
Ocular HSV can cause disease in any layer of the eye and is mainly spread by direct contact. A variety of eye diseases are associated with ocular HSV infection, including conjunctivitis, iridocyclitis, acute retinal necrosis and keratitis.