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With continued use, twice a day, every day. its also what i prescribe to my patients who have this condition. restasis multidose® helps increase your eyes natural ability to produce tears, which may be reduced by inflammation due to chronic dry eye. restasis multidose® did not increase tear production in patients using anti-inflammatory eye drops or tear duct plugs. to help avoid eye injury and contamination, do not touch the bottle tip to your eye or other surfaces. wait 15 minutes after use ...