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Researchers identify over 2,000 genetic signa

Researchers led by Queen Mary University of London and supported by the National Institute for Health and Care Research (NIHR) have discovered over a hundred new regions of the human genome, also known as genomic loci, that appear to influence a person’s blood pressure. In total, over 2,000 independent genetic signals for blood pressure are now reported, demonstrating that blood pressure is a highly complex trait influenced by thousands of different genetic variants.
United Kingdom United States City Of Markj Caulfield Mikea Nall Peter Vollenweider

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People don't mate randomly – but the flawed assumption that they do is an essential part of many studies linking genes to diseases and traits

@meanymoo, CC BY-NC-NDStatistical pitfalls in GWAS can result in misleading conclusions about whether some traits (like long horns or spotted skin, in the case of dinosaurs) are genetically linked.   The idea that correlation does not imply caus...
United States Los Angeles Noah Zaitlen University Of California Postdoctoral Researcher Statistical Genetics

New online resource helps connect rare genetic variants to human health and disease

In 2006, researchers discovered that people with certain variants of the gene PCSK9 had dramatically lower cholesterol levels than the general population. Individuals with two broken copies of the gene — one from each parent — were up to 88 percent less likely to have coronary heart disease than people with functioning PCSK9 .
Katherine Chao Konrad Karczewski Matthew Solomonson Benjamin Neale Broad Institute National Institutes Of Health

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