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Findings were published in Science. The modeling technique invented by Andrey Morgun of the OSU College of Pharmacy and Natalia Shulzenko of Oregon State’s Carlson College of Veterinary Medicine is known as transkingdom network analysis. The human gut microbiome is a community of more than 10 trillion microbial cells from about 1,000 different bacterial species, and transkingdom network analysis integrates multiple types of “omics” data – metagenomic, metabolomic, lipidomic, proteomic, etc. – in determining how interactions among specific types of gut microbes help or hinder biological functions in the host. In this case, the microbial interactions involved how well the body responds to a type of cancer treatment known as anti-programmed cell death protein therapy, abbreviated to anti-PD-1 therapy. It allows immune cells to react more strongly to cancer.

Diwakar davarNatalia shulzenkoAmiran dzutsevHassane zarourGiorgio trinchieriRichard rodriguesNational institute of healthNational cancer instituteUniversity of pittsburghCollege of pharmacyOregon state carlson college of veterinary medicineOregon state universityAndrey morgunOregon stateCarlson collegeVeterinary medicine