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Cureus | The Relationship Between COVID-19 Disease Severity and Zonulin Levels

Introduction Zonulin is a protein that plays a role in the reversible regulation of epithelial permeability. As zonulin is released in large amounts into the intestinal lumen, it disrupts the integrity of the tight junctions and causes continuous migration of antigens to the submucosa. Consequently, it can trigger inflammatory processes and severe immune reactions. In severe cases, SARS-CoV-2 may have a major impact on the clinical manifestations of the disease by directly or indirectly affectin...
United States Amasya Sabuncuo Bioeksen Bio Research Hospital Infectious Diseases Clinic University Clinical Research Ethics Committee Approval Statistical Package For Social Sciences
Source: cureus.com

Cureus | A Retrospective Cohort Study on Diabetic Foot Disease: Ascertainment of Ulcer Locations by Age Group

Background and aims Diabetic foot ulcer location is a known independent predictor for cure with a better healing gradient proximal to distal. Although advanced age is one of the main factors associated with greater diabetic foot ulcer severity, there are no studies evaluating diabetic foot ulcer location specifically in the elderly population in an outpatient setting. This study evaluated diabetic foot ulcer location and age-group interactions in diabetic foot presentation. Methods A retrospecti...
EtelÀuomen LÀi United States Centro Hospitalar Universit Stage Of University Texas Statistical Package For Social Sciences Ethics Committee Of Centro Hospitalar Universit
Source: cureus.com

Six-year prognosis of anxiety and depression caseness and their comorbidity in a prospective population-based adult sample | BMC Public Health

Anxiety and depression are amongst the most prevalent mental health problems. Their pattern of comorbidity may inform about their etiology and effective treatment, but such research is sparse. Here, we document long-term prognosis of affective caseness (high probability of being a clinical case) of anxiety and depression, their comorbidity, and a no-caseness condition at three time-points across six years, and identify the most common prognoses of these four conditions. Longitudinal pop...
Monte Carlo Environmental Health Study Statistical Package For The Social Sciences Hospital Anxiety Depression Scale Statistical Package

Cureus | Outcomes of Biliary Atresia in a Single Center in Jeddah, Saudi Arabia

Background Biliary atresia (BA) is a rare but severe cause of obliterative cholangiopathy in neonates. Its incidence differs worldwide varying from 5/100,000 to 32/100,000 live births. The highest incidence is seen in Asia and the Pacific region. Diagnosing this disease is difficult in its early stages; thus, screening is necessary to avoid serious complications that can be minimized with early intervention during the first few months of life. Currently, although there are no medical treatments ...
United States Saudi Arabia Research Ethics International Classification Of Diseases King Abdulaziz University Hospital Pediatric Department
Source: cureus.com

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Cureus | Mortality and Its Predictors in COVID-19 Patients With Pre-existing Interstitial Lung Disease

Background The data on the impact of coronavirus disease 2019 (COVID-19) on interstitial lung disease (ILD) is still limited. To the best of our knowledge, there has been no study from India to date to assess the impact of COVID-19 in patients with preexisting ILD. We undertook this study to assess the clinical outcome of ILD patients admitted to our hospital with COVID-19. Methods In this retrospective observational study, records of reverse transcription polymerase chain reaction (RT-PCR)-conf...
United States Jaks Janus Statistical Package For Social Sciences World Health Organization All India Institute Medical Sciences Institutional Ethics Committee
Source: cureus.com

Cureus | Transmission and Cleaning Misconception During the COVID-19 Pandemic Time in Riyadh, Saudi Arabia

Objectives: This study aimed to investigate the knowledge and attitude of the public in Saudi Arabia toward the concept of surface decontamination during the COVID-19 pandemic. Methods: A cross-sectional, web-based study was conducted over six months, from February 2021 to July 2021. We included adult Saudi and non-Saudi males and females living in Riyadh, Saudi Arabia.  Results: Six hundred and twenty-six responses from Saudi (92.7%) and non-Saudi (7.3%) participants with a median age of...
Riyadh Region Ar Riya Saudi Arabia United States Centers For Disease Environmental Protection Agency
Source: cureus.com

Cureus | Knowledge, Attitudes, and Practices of COVID-19 Safety Measures Among Type 1 Diabetes Mellitus Patients at King Abdulaziz University Hospital: A Cross-Sectional Study

Background: Coronavirus disease 2019 (COVID-19), an infectious disease caused by an enveloped RNA beta coronavirus, has become a pandemic, with a mortality rate ranging from 0.7% to 10.8%. Although older adults with comorbidity are more likely to suffer severe disease and eventual mortality, diabetes mellitus (DM) is one of the most frequently reported noncommunicable diseases shown to predict poor prognosis in COVID-19 patients. Aim: To determine the knowledge, attitudes, and practices (KAP) ...
United States United Kingdom Mountain View Saudi Arabia Saudi Arabian International Classification Of Diseases
Source: cureus.com

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