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Unlocking the secrets of long-lived hematopoietic stem cells

Nothing lives forever, but compared to other cells in the body, hematopoietic stem cells (HSCs) are remarkably long-lived. HSCs are blood-forming cells – they give rise to rapidly dividing progenitor cells, which in turn generate hundreds of billions of cells to fulfill the daily demand of oxygen-delivering red blood cells, disease-fighting white blood cells and clot-forming platelets.
Danielas Krause Ergun Sahin Francis Tf Tsai Charlesg Lee Shannone Moree Polina Iakova

U of T researchers develop new approach for controlling neuron generation in Parkinson's disease

Researchers at the University of Toronto have found a way to better control the preclinical generation of key neurons depleted in Parkinson's disease, pointing toward a new approach for a disease with no cure and few effective treatments.
Mandy Yang Donnelly Centre University Of Toronto Donnelly Centre For Cellular Stephane Angers Leslie Dan Faculty

Unlocking the mechanisms of pluripotent cell's fate determination

As embryos, all complex organisms are partially made up of pluripotent stem cells, a term for cells that have the capacity to differentiate into any kind of cell: nerve cells, muscle cells, blood cells, skin cells, and the like.
Sharon Torigoe Research In Undergraduate Institutions Rogers Science Research Program National Science Foundation Lewis Clark College Undergraduate Institutions

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Study finds rise in volumes and survival after hematopoietic cell transplants among racial/ethnic minorities

The volume of hematopoietic cell transplants rose among all racial/ethnic groups, but grew faster among African Americans and Hispanics compared with Non-Hispanic white individuals, mirroring changes in population growth rates.
United States Theresa Hahn Nandita Khera Roswell Park Comprehensive Cancer Center American Society Of Transplantation American Society Of Hematology

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