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Stanford chemists uncover new pathway for protein degradation, opening door to new therapeutics

When targeting problem proteins involved in causing or spreading disease, a drug will often clog up a protein's active site so it can't function and wreak havoc.

United kingdomUnited statesCarolyn bertozziLily ramseySteven banikUniversity of washington institute for protein designSchool of humanitiesBaker family directorGreen ahnWashington instituteProtein designDrug discoveryLysosomal storage disorders

Unlocking pathways to break down problem prot

<p>Stanford researchers who previously pioneered a new kind of protein degradation have mapped out how the process works, which could lead to new drug therapies for diseases like Alzheimer’s and cancer, and for rare childhood enzyme disorders.</p>

United kingdomUnited statesStanford biox bassikNicholas rileySteven banikMichael bassikCarolyn bertozziSimon wisnovskyEngineering research council of canadaUniversity of washington institute for protein designUniversity of british columbiaCanadian glycomics networkNational institutes of healthCanadian institutes of health researchStanford cancer instituteNational science foundation

New protein destruction target pathway

New protein destruction target pathway
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United statesUnited kingdomSteven banikMichael bassikStanford biox bassikCarolyn bertozziSimon wisnovskyNicholas rileyWu tsai neurosciences instituteUniversity of washington institute for protein designSchool of medicineEngineering research council of canadaCancer research societyNational institutes of healthUniversity of british columbiaNatural sciences

New Pathways Unlocked to Dismantle Problem Proteins

New Pathways Unlocked to Dismantle Problem Proteins
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United statesUnited kingdomSteven banikMichael bassikStanford biox bassikSimon wisnovskyCarolyn bertozziNicholas rileyUniversity of british columbiaCancer research societyNatural sciencesMaternal child health research instituteNational institutes of healthStanford cancer instituteSchool of medicineCanadian glycomics network

Unlocking pathways to break down problem proteins presents new treatment opportunities

Unlocking pathways to break down problem proteins presents new treatment opportunities
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United kingdomUnited statesSteven banikCarolyn bertozziUniversity of washington institute for protein designSchool of humanitiesBaker family directorGreen ahnWashington instituteProtein design