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Evusheld significantly protected against symptomatic COVID-19 for at least six months in PROVENT Phase III trial in high-risk populations

Detailed results from the PROVENT Phase III pre-exposure prophylaxis (prevention) trial showed that AstraZeneca’s Evusheld (tixagevimab and cilgavimab), formerly AZD7442, reduced the risk of developing symptomatic COVID-19 by 77% in the primary analysis and by 83% in the six month follow-up analysis, compared to ...

Detailed results from the PROVENT Phase III pre-exposure prophylaxis trial showed that AstraZeneca’s Evusheld, formerly AZD7442, reduced the risk of...

The spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has become a pandemic due to the high transmission and mortality rate of this virus. The world health and economic sectors have been severely affected by this deadly virus, exacerbated by the lack of sufficient efficient vaccines. The design of effective drug candidates and their rapid development is necessary to combat this virus. In this study, we selected 23 antimicrobial peptides from the literature and predicted thei...

A recent study reveals that nirmatrelvir is potent and effective against the SARS-CoV-2 Omicron variant.

Researchers in the United States and Canada have described the structural basis and mode of action for two monoclonal antibodies that potently neutralize severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) – the agent that causes coronavirus disease 2019 (COVID-19).

The equine navicular enthesis organ, showing structures of the navicular apparatus. Image: Osborne, Blas-Machado, Cornille, Uhl “Navicular” is a diagnosis that nobody wants to hear. The prognosis is often poor, resulting in full or partial retirement of the horse. Equine Science Foundation co-founder Paige LaBella looks at a review of the latest research, which suggests navicular syndrome might be preventable. Navicular is usually associated with front foot pain and damage to the navicular ...

Organisms with linear chromosomes have to solve the problem that DNA replication makes them shorter. This is due to the fact that DNA polymerase can only add bases to the terminal 3-OH of a DNA chain. The DNA replication initiation complex uses RNA primers to provide the initial 3-OH and to initiate "lagging" strand synthesis.  While one strand can be copied all the way to the end of a chromosome, the other, lagging strand, must be primed at short intervals in order to provide a 3 OH group for...

At its meeting of 9 and 10 December 2020 and upon application of Joël Mesot, President of ETH Zurich, the ETH Board appointed 14 professors. They will work in a total of ten departments in a wide range of research areas. In addition, an ecotoxicologist was awarded the title of professor. The new professors in brief: Dr Pierrick Bousseau (*1992), currently CNRS Research Fellow at the University of Paris-Saclay, France, as Assistant Professor of Mathematical Physics in the Department of Mathemat...