Revealing way a critical enzyme works in cell miragenews.com - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from miragenews.com Daily Mail and Mail on Sunday newspapers.
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Addex Reports Full Year 2020 Financial Results and Provides Corporate Update
Addex TherapeuticsMarch 11, 2021 GMT
Strong cash and cash equivalents position at Dec 31, 2020 of $20.2M (CHF18.7M)
Balance sheet further strengthened by $11.5M fundraising on January 11, 2021
Three clinical studies in neurology programs expected to start during H1 2021
Clinical stage neurology programs aimed at large underserved market opportunities (Epilepsy, Parkinson’s disease LID and Blepharospasm)
Geneva, Switzerland, March 11, 2021 – Addex Therapeutics (SIX: ADXN and Nasdaq: ADXN), a clinical-stage pharmaceutical company pioneering allosteric modulation-based drug discovery and development, today reported financial results for the full-year ended December 31, 2020 and provided a corporate update.
Credit: Gisou van der Goot (EPFL)
S-acylation is the process of chemically linking a lipid to protein via a thioester bond. It is an important process of the cell that regulates the localization and function of numerous proteins. It promotes lipid membrane association of the protein, for instance to the plasma membrane, Golgi apparatus, or inner nuclear membrane.
Like most biochemical processes in the cell, protein S-acylation is reversible to regulate the functions of acylated proteins. S-acylation is reversed by the enzymes acyl protein thioesterases (APTs).
To do their work, APTs have to interact with the lipid membranes that their target proteins are bound to. But even though APTs are central to the important acylation deacylation process little is known about how APTs carry out their functions.
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