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KIBRA restores tau-driven damage in Alzheimer's disease

It is well known that protein tau forms aggregates in the brain in neurodegenerative diseases such as Alzheimer’s disease (AD) that are also known as tauopathies. Accumulation of protein tau in the brain leads to the cell toxicity and promotes the loss of synaptic plasticity, which in turn causes memory loss. As reported on Feb. 1, 2024, in The Journal of Clinical Investigation, assistant professor Tara Tracy and her research team from the Buck Institute for Research on Aging have discovered a...
Tara Tracy Buck Institute For Research On Clinical Investigation Buck Institute Bioworld Science Alzheimers Disease

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"The mTOR/NF-κB Pathway Mediates Neuroinflammation and Synaptic Plastic" by Ting Xu, Jiao Liu et al.

Abstract Diabetic encephalopathy, a severe complication of diabetes mellitus, is characterized by neuroinflammation and aberrant synaptogenesis in the hippocampus leading to cognitive decline. Mammalian target of rapamycin (mTOR) is associated with cognition impairment. Nuclear factor-κB (NF-κB) is a transcription factor of proinflammatory cytokines. Although mTOR has been ever implicated in processes occurring in neuroinflammation, the role of this enzyme on NF-κB signaling pathway remains ...
Diabetic Encephalopathy F κb Synaptic Plasticity
Source: uow.edu.au

NIMH » Trainee Successes: Past & Present

Shahriar SheikhBahaei, Ph.D. Dr. SheikhBahaei’s interest in neuroscience stemmed from the usual combination of an aptitude for science and a medical problem (stuttering) that brought him into bioscience at a young age. Dr. SheikhBahaei received his bachelor’s degree from the University of California at Berkeley, where he worked with Dr. Bob Zucker on the regulation of neurotransmitter release and Dr. John Rubenstein (UC San Francisco) on development of GABAergic neurons in basal ganglia. Dr...
United States City Of United Kingdom Cornell University New York University Of Denver
Source: nih.gov

What the Pandemic Is Doing to Our Brains

The Atlantic We have been doing this so long, we’re forgetting how to be normal. Peter Marlow / Magnum I first became aware that I was losing my mind in late December. It was a Friday night, the start of my 40-somethingth pandemic weekend: Hours and hours with no work to distract me, and outside temperatures prohibitive of anything other than staying in. I couldn’t for the life of me figure out how to fill the time. “What did I used to … do on weekends?” I asked my boyfriend, like a s...
United States Cape Elizabeth Rachel Kowert Tina Franklin Jen George Kylie Brakeman

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