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"Sex as a Predictor of Response to Immunotherapy in Advanced Cutaneous " by Nicholas Yeo, Benjamin Genenger et al.

Approximately 3โ€“5% of patients with cutaneous squamous cell carcinoma (CSCC) develop advanced disease, accounting for roughly 1% of all cancer deaths in Australia. Immunotherapy has demonstrated significant clinical benefit in advanced CSCC in several key phase II studies; however, there are limited data for patients treated outside of clinical trials. This is particularly relevant in advanced CSCC, which is most often seen in elderly patients with significant comorbidities. Thus, we aim to de...
Shoalhaven Local Health District Shoalhaven Local Health Utaneous Squamous Cell Cancer T Cell
Source: uow.edu.au

Exploring the dual role of nirmatrelvir and bisphosphonates in COVID-19 treatment and immunity

Review examines nirmatrelvir and bisphosphonates in treating COVID-19, revealing their impact on SARS-CoV-2-specific adaptive immunity and potential to mitigate severe infections, highlighting the need for balanced long-term immunity management.
Molecular Immunology Coronavirus Disease Covid 19 Ars Cov 2 Immune System Evere Acute Respiratory Evere Acute Respiratory Syndrome

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Gene therapy's double-edged sword: Breakthrough treatments face manufacturing and efficacy

Research explores the advancements, challenges, and economic implications of gene therapy for various diseases, including inherited blood disorders, malignancies treated with CAR-T cells, and diseases targeted by in vivo AAV vectors. The review highlights the transformative potential of gene therapies while acknowledging the complexities in manufacturing, safety, efficacy, and long-term durability.
Drug Administration Contract Development Gene Therapy Major Histocompatibility Complex B Cell Maturation Antigen Inverted Terminal Repeats

Novel replacement strategy holds promise for the treatment of various genetic disorders

Severe Combined Immunodeficiencies (SCIDs) are a group of debilitating primary immunodeficiency disorders, primarily caused by genetic mutations that disrupt T-cell development. SCID can also affect B-cell and natural killer cell function and counts.
Immunodeficiencies Scids Danielle Ellis Ayal Hendel Ilan University Ilan University Goodman Faculty Of Life Sciences Nature Communications

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