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Frontiers | Chagas Disease Drug Discovery in Latin America—A Mini Review of Antiparasitic Agents Explored Between 2010 and 2021

Chagas disease is a neglected tropical disease caused by the protozoan parasite Trypanosoma cruzi that endangers almost 70 million people worldwide. The only two drugs that are currently approved for its treatment, benznidazole and nifurtimox, have controversial efficacy in adults and restricting safety issues, leaving thousands of patients without a suitable treatment. The neglect of Chagas disease is further illustrated by the lack of a robust and diverse drug discovery and development portfol...
United States El Salvador Pilar Manzano Fonseca Murta Oswaldo Cruz Van Huijsduijnen

New substance suppresses the growth of harmful bacteria that cause periodontitis

New substance suppresses the growth of harmful bacteria that cause periodontitis Targeted, efficient and with few side effects: A new method for combating periodontitis could render the use of broad-spectrum antibiotics superfluous. It was developed and tested for the first time by a team from Martin Luther University Halle-Wittenberg (MLU), the Fraunhofer Institute for Cell Therapy and Immunology IZI and Periotrap Pharmaceuticals GmbH. The aim is to neutralize only bacteria that cause periodon...
Miltont Stubbs Mirko Buchholz Emily Henderson Periotrap Pharmaceuticals Gmb Martin Luther University Halle Wittenberg Jagiellonian University In Krakow

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