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This Viewpoint examines whether overdiagnosis rather than underdiagnosis may now be the dominant form of myocardial infarction misdiagnosis.

United statesUnited kingdomJamesl januzzi jrAmerican college of cardiologyImbria pharmaceuticalsBoehringer ingelheimEngland comparative effectiveness public affairs councilAbbott laboratoriesNational heartBaim institute for clinical researchWomen heart attack research programBlood institute career development awardCardiology divisionNational institutes of healthUniversal definitionMyocardial infarction