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Mice study shows how working memory is maintained across interconnected brain regions

How does the brain keep in mind a phone number before dialing? Working memory is an essential component of cognition, allowing the brain to remember information temporarily and use it to guide future behavior.

Study: Working memory is reliant on cross-brain interactions

Research reveals working memory depends on cross-brain interactions

Study shows how the brain represents causally-controlled objects

Study shows how the brain represents causally-controlled objects We know that the brain can direct thoughts, but how this is achieved is difficult to determine. Researchers at the Sainsbury Wellcome Centre have devised a brain machine interface (BMI) that allows mice to learn to guide a cursor using only their brain activity. By monitoring this mouse-controlled mouse moving to a target location to receive a reward, the researchers were able to study how the brain represents intentional control. The study, published today in Neuron, sheds light on how the brain represents causally-controlled objects. The researchers found that when mice were controlling the cursor, brain activity in the higher visual cortex was goal-directed and contained information about the animal's intention. This research could one day help to improve BMI design.

Mice taught to guide computer mouse with brain activity

Mouse-controlled mouse helps researchers understand intentional control

Loading video... VIDEO: Top panel, from top to bottom: Run, licking and brain activity during training. Animals had to increase activity in control region 1 (R1, blue) compared to control region 2 (R2,... view more  Credit: Sainsbury Wellcome Centre We know that the brain can direct thoughts, but how this is achieved is difficult to determine. Researchers at the Sainsbury Wellcome Centre have devised a brain machine interface (BMI) that allows mice to learn to guide a cursor using only their brain activity. By monitoring this mouse-controlled mouse moving to a target location to receive a reward, the researchers were able to study how the brain represents intentional control.