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Alzheimers Patients Survival Bolstered by Donepezil, Memantine Combo

Alzheimer's disease is the world's most common neurodegenerative disease, affecting more than 50 million people globally. Alzheimer's disease is also

United statesCyril rakovskiEhsan yaghmaeiChapman universityData sciencesUc irvine school of medicineChapel hill school of medicineCommunications medicineProgram directorOrange county

Cutting the cable between CD8+ T and T regulatory cells enhances checkpoint immunotherapy

Checkpoint immunotherapy utilizing PD-1 blockade has become the standard of care for metastatic melanoma. While this treatment is effective in 40% of patients, the other 60% develop resistance, leading to tumor regrowth. A multidisciplinary research team led by the University of California, Irvine has identified a new strategy that could enhance the therapeutic effectiveness of this therapy by targeting the communication between immune cells within the tumor.

Irvine schoolUnited statesFrancesco marangoniShannon geelsMultiscale cell fate researchUc irvine school of medicineUniversity of californiaSaint john cancer institute in santa monicaDepartment of physiology biophysicsUniversity of alabama at birminghamInstitute for immunologyHarvard medical schoolCancer cellComplex biological systemsSimons centerSaint john

Circadian clock can be leveraged to enhance cancer immunotherapy

A multidisciplinary research team has revealed that the circadian clock the biological pacemaker that governs daily rhythms in physiological processes, including immune functions can be leveraged to enhance the efficacy of checkpoint inhibitor cancer therapy. Checkpoint inhibitors block different proteins from binding to tumor cells, allowing the immune system s T cells to kill the tumor.

Selma masriV foundationUc irvine school of medicineDepartment of biological chemistryNational cancer instituteNature immunologyBridget fortin

Circadian Clock Boosts Cancer Immunotherapy, UCI Study Finds

Circadian Clock Boosts Cancer Immunotherapy, UCI Study Finds
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United statesIrvine schoolOrange countyHoward gillmanSelma masriUc irvine school of medicineDepartment of biological chemistryUniversity of californiaNational cancer instituteV foundationAssociation of american universitiesNature immunologyBridget fortinAmerican universitiesChancellor howard gillman

Study reveals circadian clock can be leveraged to enhance cancer immunotherapy

Study reveals circadian clock can be leveraged to enhance cancer immunotherapy
medicalxpress.com - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from medicalxpress.com Daily Mail and Mail on Sunday newspapers.

United statesIrvine schoolBridgetm fortinSelma masriUc irvine school of medicineUniversity of californiaDepartment of biological chemistryNature immunologyBridget fortin