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Alzheimers Patients Survival Bolstered by Donepezil, Memantine Combo

Alzheimer's disease is the world's most common neurodegenerative disease, affecting more than 50 million people globally. Alzheimer's disease is also

'Cutting the cable' between CD8+ T and T regulatory cells enhances checkpoint immunotherapy

Checkpoint immunotherapy utilizing PD-1 blockade has become the standard of care for metastatic melanoma. While this treatment is effective in 40% of patients, the other 60% develop resistance, leading to tumor regrowth. A multidisciplinary research team led by the University of California, Irvine has identified a new strategy that could enhance the therapeutic effectiveness of this therapy by targeting the communication between immune cells within the tumor.

Circadian clock can be leveraged to enhance cancer immunotherapy

A multidisciplinary research team has revealed that the circadian clock the biological pacemaker that governs daily rhythms in physiological processes, including immune functions can be leveraged to enhance the efficacy of checkpoint inhibitor cancer therapy. Checkpoint inhibitors block different proteins from binding to tumor cells, allowing the immune system s T cells to kill the tumor.

Circadian Clock Boosts Cancer Immunotherapy, UCI Study Finds

Study reveals circadian clock can be leveraged to enhance cancer immunotherapy