Researchers explore link between intestinal microbiota with colon cancer in patients with Lynch Syndrome
The researcher Gabriela Debesa, member of the research group at Simbiosis led by Andrés Moya at the Foundation for the Promotion of Health and Biomedical Research of Valencia Region (Fisabio), studied the relationship of the intestinal microbiota with colon cancer in patients with Lynch Syndrome (a hereditary illness that predisposes the development of cancer) using tissue samples in formalin and conserved in paraffin.
The main objective was to figure out if it is possible to obtain information of the microbiome based on samples conserved in this way. This was studied in samples of patients with Lynch syndrome that had developed colon cancer and it was compared if there were differences between the bacterial DNA sequences of the intestinal mucous as well as those of the tumors.