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CSF Test Predicts Brain Cancer Response to Immunotherapies March 8, 2021 Credit: Alfred Pasieka/Science Photo LIB / Getty Images/Science Photo Libra Brain metastases are the most common tumor of the brain with a very poor prognosis. A fraction of patients with brain metastasis benefit from treatment with immune checkpoint inhibitors like anti-PD1, anti-PD-L1, and anti-CTLA4 drugs. One of the limitations of these drugs over the long-term in brain tumors is that the cancers often recur, metastacizing with new lesions that don’t respond to immune-based therapies.  Unfortunately, given the unique environment of brain cancers, and the difficulty in accessing ongoing samples of brain cancers, physicians are not currently able to monitor the evolution of these cells, and the level of immune cell infilatration, at a genomic level.

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