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Apoptotic stress causes mtDNA release during senescence and drives the SASP

Senescent cells drive age-related tissue dysfunction partially through the induction of a chronic senescence-associated secretory phenotype (SASP)1. Mitochondria are major regulators of the SASP; however, the underlying mechanisms have not been elucidated2. Mitochondria are often essential for apoptosis, a cell fate distinct from cellular senescence. During apoptosis, widespread mitochondrial outer membrane permeabilization (MOMP) commits a cell to die3. Here we find that MOMP occurring in a sub...
United Kingdom Adooq Biosciences Tocris Bioscience Antifade Mountant Gencode Grch Bruker Ct
Source: nature.com

Catapult Launches Vector Core, Expanding Its Portfolio of Athlete Monitoring Solutions to Reach More Teams Globally

Vector Core is a user-friendly athlete monitoring solution that provides teams with limited resources the data and insights previously only accessible to advanced teams.Boston, MA, May 17, 2023 --... | May 17, 2023
United States Matt Bairos Valur Football Club Assistant Coach Sigurdur Hoskuldsson Duke University First Team University Of Georgia

Telomere Twist: Unraveling the Hidden Protein Secrets of Cancer and Aging

Researchers Jack Griffith and Taghreed Al-Turki from the UNC School of Medicine have discovered that telomeres, located at the ends of chromosomes, possess enough genetic information to produce two small proteins with potentially potent biological properties. Telomeres, previously believed to be
United States Taghreedm Al Turki Jackd Griffith Taghreed Al Turki Jack Griffith Proceedings Of The National Academy Science

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Viralgen receives cGMP certification to produce rAAV commercial grade product at new facility in San Sebastian, Spain

Viralgen Vector Core (Viralgen), an independently operated subsidiary of Asklepios BioPharmaceutical, Inc. (AskBio), and a member of the Bayer worldwide group of companies, has received Certified Good Manufacturing Practices (cGMP) certification for the manufacture of human medicinal products, investigational ...
San Sebastian Pais Vasco Jimmy Vanhove R Jude Samulski Javier Garc Contract Development

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