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BioAtla Conditionally Active Biologic Antibody Design And Functionality For Cancer Treatment Described In Leading Scientific Journal Peer-Reviewed Paper

Share this article Share this article SAN DIEGO, Feb. 22, 2021 /PRNewswire/ -- BioAtla, Inc., a global clinical-stage biotechnology company focused on the development of Conditionally Active Biologic (CAB) antibody therapeutics, today announced the publication by Proceedings of the National Academy of Sciences (PNAS) that describes the design and functionality of therapeutic antibody candidates utilizing BioAtlas proprietary CAB technology making them active only in the acidic tumor microenviro...
San Diego United States Lawrence Steinman Richard Waldron Hwai Wen Chang Haizhen Liu

Moffitt researchers identify how cancer cells adapt to survive harsh tumor microenvironments

 E-Mail TAMPA, Fla. - Cells need energy to survive and thrive. Generally, if oxygen is available, cells will oxidize glucose to carbon dioxide, which is very efficient, much like burning gasoline in your car. However, even in the presence of adequate oxygen, many malignant cells choose instead to ferment glucose to lactic acid, which is a much less efficient process. This metabolic adaptation is referred to as the Warburg Effect, as it was first described by Otto Warburg almost a century ago....
Mehdi Damaghi Otto Warburg Robert Gillies Cancer Physiology Department National Cancer Institute Proceedings Of The National Academy Sciences

Why cancer cells waste so much energy

Credits: Courtesy of the researchers *Terms of Use: Images for download on the MIT News office website are made available to non-commercial entities, press and the general public under a Creative Commons Attribution Non-Commercial No Derivatives license. You may not alter the images provided, other than to crop them to size. A credit line must be used when reproducing images; if one is not provided below, credit the images to "MIT." ...
Zhaoqi Li Matthew Vander Heiden Otto Warburg Vander Heiden Alice Wallenberg Foundation National Institutes Of Health
Source: mit.edu

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