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How a 7th Grade Science Project Set a Little Girl on the Path to Become a Leading COVID-19 Antibody Researcher

Updated: 10:37 AM PST, March 10, 2021 Dr. Rianna Vandergaast’s path as a lead researcher in COVID-19 neutralizing antibody testing began with a simple, seventh grade science project. Dr. Rianna Vandergaast’s path as a lead researcher in COVID-19 neutralizing antibody testing began with a simple, seventh grade science project. Her father, an environmental scientist, was the one who suggested they collect water samples from people in their own neighborhood. “We actually went around to our n...
United States Stephenj Russel Rianna Vandergaast Regeneron Pharmaceuticals University Of Wisconsin World Reference Center

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Structure-guided multivalent nanobodies block SARS-CoV-2 infection and suppress mutational escape

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic continues to spread with devastating consequences. For passive immunization efforts, nanobodies have size and cost advantages over conventional antibodies. Here, we generated four neutralizing nanobodies that target the receptor-binding domain of the SARS-CoV-2 spike protein. We defined two distinct binding epitopes using x-ray crystallography and cryo-electron microscopy. Based on the structures, we engineered multivalent...
United States Baden Wuberg Nordrhein Westfalen Karolinska Institutet Myone Streptavidin Stephan Poehlmann

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