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Scientists at Scripps Research have clarified the workings of a mysterious protein called Gαo, which is one of the most abundant proteins in the brain and, when mutated, causes severe movement disorders.
The findings, which appear in
Cell Reports, are an advance in the basic understanding of how the brain controls muscles and could lead to treatments for children born with Gαo-mutation movement disorders. Such conditions known as GNAO1-related neurodevelopmental disorders were discovered only in the past decade, and are thought to affect at least hundreds of children around the world. Children with the disease suffer from severe developmental delays, seizures and uncontrolled muscle movements.
Obesity drives risk for COVID-19 among Latino patients with rheumatic disease ADD TOPIC TO EMAIL ALERTS Receive an email when new articles are posted on Please provide your email address to receive an email when new articles are posted on . Subscribe ADDED TO EMAIL ALERTS
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Latino patients with rheumatic disease have a high rate of COVID-19, with obesity identified as a key risk factor for infection, which, in turn, was linked to increased risk for rheumatic disease flare, according to data.
By Rich McManus
NIAID’s Dr. Helen Su
When the global pandemic caused by a novel coronavirus made its debut in late 2019, NIAID’s Dr. Helen Su was studying inborn errors of immunity in patients with viral infections, mostly rhinoviruses, which cause colds, and influenza. Why, she wondered, was there such variability of outcomes in people infected with the same virus?
In a remarkable example of the NIH Intramural Research Program’s nimbleness, she and her colleagues quickly pivoted to studies of SARS-CoV-2 when it became apparent that Covid-19, the disease caused by the virus, was spreading fast and becoming, in at least a small portion of patients, life-threatening.
Harmful and Healing Responses to Brain Injury Diverge by Cellular Mediators and Time
January 20, 2021
Harmful and healing immune responses to cerebrovascular injury depend on the timing of the response and cells mediating the response, a new study reports.
Injury to blood vessels in the brain, or cerebrovascular injury, commonly caused by a stroke that blocks a blood vessel (ischemic stroke), can result in severe swelling and inflammation.
In patients with short-term blockade of a blood vessel in the brain removing a blood clot from the lumen of a prominent blood vessel to restore blood flow, is often associated with poor clinical outcomes.
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