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Effectiveness of COVID-19 Vaccines in Preventing Hospitalization Among Adults Aged ≥65 Years — COVID-NET, 13 States, February–April 2021

Effectiveness of COVID-19 Vaccines in Preventing Hospitalization Among Adults Aged ≥65 Years — COVID-NET, 13 States, February–April 2021
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Hospitalization of Adolescents Aged 12–17 Years with Laboratory-Confirmed COVID-19 — COVID-NET, 14 States, March 1, 2020–April 24, 2021

COVID-19 adolescent hospitalization rates peaked at 2.1 per 100,000 in early January 2021, declined to 0.6 in mid-March, and rose to 1.3 in April. Among hospitalized adolescents, nearly one-third required intensive care unit admission and 5% required invasive mechanical ventilation, but no associated deaths occurred.

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Researchers find genes, corresponding proteins that may lead to new depression treatments

E-Mail IMAGE: In their lab at the Atlanta VA and Emory University, Dr. Thomas Wingo and Dr. Aliza Wingo (foreground) have found genes and corresponding proteins that could open doors for new. view more Credit: Lisa Pessin Using an innovative protein-based approach, researchers at the Atlanta Veterans Affairs Medical Center and nearby Emory University have found genes and corresponding proteins that could point the way to new depression treatments. Using a proteome-wide association study (PWAS) that integrated genome-wide association study (GWAS) data with human brain proteomic and genetic data, researchers have identified 19 genes that may lead to depression by altering brain protein levels. They also pinpointed 25 such proteins that offer promise as potential targets for new depression treatments.

Thomas wingoAliza wingoAtlanta veterans affairs medical centerEmory universityNational institutes of healthEmory centerNational institutesPharmaceutical sciencesMedicine healthMental healthDepression angerResearch developmentதாமஸ் விங்கோஅலிசா விங்கோஅட்லாண்டா வீரர்கள் வாழ்க்கைத்தொழில்கள் மருத்துவ மையம்உணர்ச்சி பல்கலைக்கழகம்

Baricitinib speeds COVID-19 recovery in NIAID trial

Tags » In a randomized, controlled trial of more than 1,000 adults hospitalized with COVID-19 pneumonia, treatment with the anti-inflammatory drug baricitinib resulted in faster recovery and a greater likelihood of clinical improvement, when combined with the antiviral drug remdesivir. The results of the international ACTT-2 (Adaptive COVID-19 Treatment Trial), sponsored by the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health, were published Friday Dec. 11 in the Baricitinib was originally developed by Eli Lilly and Company for rheumatoid arthritis and was FDA-approved for that indication in 2017. The drug, part of a class of drugs that inhibits JAK enzymes, received an emergency use authorization for COVID-19 treatment in November 2020, based upon the ACTT-2 results.

Grady memorial hospitalUnited statesUniversity of cincinnatiUniversity of nebraska medical centerAndre kalilAneesh mehtaVincent marconiNadine rouphaelEli lillyJohns hopkins universityVanderbilt university medical centerEmory universityNational institute of allergyInfectious diseases clinical research consortiumUniversity of alabama at birminghamNational emerging special pathogens training