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UCI-led team creates new ultralightweight, crush-resistant tensegrity metamaterials

 E-Mail IMAGE: Novel tensegrity metamaterials by UCI and Georgia Institute of Technology researchers employ isolated compressive loop elements that are exclusively connected through a continuous network of tensile members (highlighted in magenta). view more  Credit: Jens Bauer and Cameron Crook / UCI Irvine, Calif., March 11, 2021 - Catastrophic collapse of materials and structures is the inevitable consequence of a chain reaction of locally confined damage - from solid ceramics that snap after the development of a small crack to metal space trusses that give way after the warping of a single strut. In a study published this week in Advanced Materials, engineers at the University of California, Irvine and the Georgia Institute of Technology describe the creation of a new class of mechanical metamaterials that delocalize deformations to prevent failure. They did so by turning to tensegrity, a century-old design principle in which isolated rigid bars are integrated int

UCI researchers join forces to tackle challenges in human health and the environment

UCI researchers join forces to tackle challenges in human health and the environment
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UCI researchers eavesdrop on cellular conversations

 E-Mail IMAGE: Overview of how CellChat can convert molecular language of cells into the translation that is interpretable by researchers. view more  Credit: Suoqin Jin, Qing Nie & Maksim Plikus / UCI Irvine, Calif. An interdisciplinary team of biologists and mathematicians at the University of California, Irvine has developed a new tool to help decipher the language cells use to communicate with one another. In a paper published today in Nature Communications, the researchers introduce CellChat, a computational platform that enables the decoding of signaling molecules that transmit information and commands between the cells that come together to form biological tissues and even entire organs.

Radioactive bone cement found to be safer in treating spinal tumors

 E-Mail Irvine, Calif., Feb. 16, 2021 A radioactive bone cement that s injected into bone to provide support and local irradiation is proving to be a safer alternative to conventional radiation therapy for bone tumors, according to a study led by University of California, Irvine researchers. The study shows that this brachytherapy cement can be placed into spinal bones to directly irradiate tumors without harming the spinal cord, and the radioactive material will stay localized in the bones, which promises to virtually eliminate side effects. Lead researcher Joyce Keyak, UCI professor of radiological sciences, presented the results at the 2021 annual meeting of the Orthopaedic Research Society, which was held virtually Feb. 12-16.

Federal COVID-19 response taps UCI Health methods for delivering monoclonal antibody therapy

 E-Mail Irvine, Calif., Feb. 9, 2021 Monoclonal antibodies are showing promise for improving outcomes for COVID-19 patients, but when a hospital is already beyond capacity, administering them can be a challenge. As hospitalizations soared across California, clinicians with UCI Health created a system for delivering monoclonal antibodies that is keeping hospital beds available for patients with the greatest need. The hospital bed is one of the most valuable resources that we have, which has been stretched thin by the COVID-19 pandemic, said Dr. Daniel S. Chow, an assistant professor in residence in radiological sciences and co-director for the Center for Artificial Intelligence in Diagnostic Medicine as well as the project s co-principal investigator. Every effort to expand the number of beds available counts, and that includes being proactive about preventing hospitalizations.

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