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GloboNews exibe documentário sobre a trajetória de Alcione neste domingo | Televisão
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Obra da Comusa: oito bairros de Novo Hamburgo seguem afetados pelo desabastecimento
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Obra da Comusa deve causar falta de água nesta quarta
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Obra da Comusa: veja os bairros que podem ficar sem água
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Despite recent intensification of control measures,
Plasmodium vivax poses a major challenge for malaria elimination efforts. Liver-stage hypnozoite parasites that cause relapsing infections can be cleared with primaquine; however, poor treatment adherence undermines drug effectiveness. Tafenoquine, a new single-dose treatment, offers an alternative option for preventing relapses and reducing transmission. In 2018, over 237,000 cases of malaria were reported to the Brazilian health system, of which 91.5% were due to
P.
Methods and findings
We evaluated the impact of introducing tafenoquine into case management practices on population-level transmission dynamics using a mathematical model of
P.
P.
vivax endemic settings in Brazil in 2018, informed by nationwide malaria case reporting data. Parameters for treatment pathways with chloroquine, primaquine, and tafenoquine with glucose-6-phosphate dehydrogenase deficiency (G6PDd) testing were informed by clinical trial data an