Rice University neurobiologist wins NIH grant to study enteric nervous system development
Rice University neurobiologist Rosa Uribe will be hitting the books for her latest study of the digestive system, but some of the pages in her books are a billion years old.
Uribe, an assistant professor of biosciences, has won a five-year, $2 million R01 grant from the National Institutes of Health to study how the enteric nervous system forms.
If you didn t realize you had an enteric nervous system, you re not alone.
Most people don t realize they have it until there s something wrong with it, and they have to go to the gastroenterologist. It is basically the nervous system that resides within your entire gut. It is separate from your spinal cord, and it is separate from your brain. Meaning, it can function on its own to help move the food that you digest from one end of the gut the other in a healthy way.
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IMAGE: In a mouse model and in human heart muscle cells, researchers used gene editing to modify specific DNA sequences and restore dystrophin production in mutant dystrophin genes. view more
Credit: UT Southwestern Medical Center
DALLAS - April 30, 2021 - UT Southwestern scientists successfully employed a new type of gene therapy to treat mice with Duchenne muscular dystrophy (DMD), uniquely utilizing CRISPR-Cas9-based tools to restore a large section of the dystrophin protein that is missing in many DMD patients. The approach, described online today in the journal
Science Advances, could lead to a treatment for DMD and inform the treatment of other inherited diseases.
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Rice University neurobiologist Rosa Uribe will be hitting the books for her latest study of the digestive system, but some of the pages in her books are a billion years old.
Uribe, an assistant professor of biosciences, has won a five-year, $2 million R01 grant from the National Institutes of Health to study how the enteric nervous system forms.
If you didn’t realize you had an enteric nervous system, you’re not alone.
“Most people don’t realize they have it until there’s something wrong with it, and they have to go to the gastroenterologist,” Uribe said. “It is basically the nervous system that resides within your entire gut. It is separate from your spinal cord, and it is separate from your brain. Meaning, it can function on its own to help move the food that you digest from one end of the gut the other in a healthy way.”
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IMAGE: Neurodevelopmental biologist Rosa Uribe is a CPRIT Scholar and assistant professor of biosciences at Rice University. view more
Credit: Photo by Jeff Fitlow/Rice University
HOUSTON - (May 10, 2021) - Rice University neurobiologist Rosa Uribe will be hitting the books for her latest study of the digestive system, but some of the pages in her books are a billion years old.
Uribe, an assistant professor of biosciences, has won a five-year, $2 million R01 grant from the National Institutes of Health to study how the enteric nervous system forms.
If you didn t realize you had an enteric nervous system, you re not alone.
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Single-cell map of early stage lung cancer and normal lung sheds light on tumor development, new therapeutic targets
Researchers at The University of Texas MD Anderson Cancer Center have developed a first-of-its-kind spatial atlas of early-stage lung cancer and surrounding normal lung tissue at single-cell resolution, providing a valuable resource for studying tumor development and identifying new therapeutic targets. The study was published today in Cancer Discovery, a journal of the American Association for Cancer Research.
The findings reveal a heterogeneous lung cancer ecosystem, with extensive interactions between cancer cells and the surrounding microenvironment that regulate early cancer development. By studying the crosstalk between the tumor and surrounding immune cells, researchers identified and validated CD24, an immune checkpoint protein, as a new immunotherapy target for lung cancer treatment.