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New Software Improves Accuracy of Mass-Produced 3D Printed Parts
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IMAGE: The software can detect defects in the printed parts and determine where in the printer the defects occur. view more
Credit: University of Illinois Urbana-Champaign
Researchers at University of Illinois Urbana-Champaign developed software to improve the accuracy of 3D-printed parts, seeking to reduce costs and waste for companies using additive manufacturing to mass produce parts in factories. Additive manufacturing is incredibly exciting and offers tremendous benefits, but consistency and accuracy on mass-produced 3D-printed parts can be an issue. As with any production technology, parts built should be as close to identical as possible, whether it is 10 parts or 10 million, said Professor Bill King, Andersen Chair in the Department of Mechanical Science and Engineering and leader of the project.
Direct cloning method aims to accelerate large-scale discovery of novel natural products
Microorganisms possess natural product biosynthetic gene clusters (BGCs) that may harbor unique bioactivities for use in drug development and agricultural applications. However, many uncharacterized microbial BGCs remain inaccessible. Researchers at University of Illinois Urbana-Champaign previously demonstrated a technique using transcription factor decoys to activate large, silent BGCs in bacteria to aid in natural product discovery.
Now, they have developed a direct cloning method that aims to accelerate large-scale discovery of novel natural products. Their findings are reported in the journal
Nature Communications.
Named Cas12a assisted precise targeted cloning using in vivo Cre-lox recombination (CAPTURE), the method allows for direct cloning of large genomic fragments, including those with high-GC content or sequence repeats. Where existing direct cloning methods fail to effectively c
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Microorganisms possess natural product biosynthetic gene clusters (BGCs) that may harbor unique bioactivities for use in drug development and agricultural applications. However, many uncharacterized microbial BGCs remain inaccessible. Researchers at University of Illinois Urbana-Champaign previously demonstrated a technique using transcription factor decoys to activate large, silent BGCs in bacteria to aid in natural product discovery.
Now, they have developed a direct cloning method that aims to accelerate large-scale discovery of novel natural products. Their findings are reported in the journal
Nature Communications.
Named Cas12a assisted precise targeted cloning using in vivo Cre-lox recombination (CAPTURE), the method allows for direct cloning of large genomic fragments, including those with high-GC content or sequence repeats. Where existing direct cloning methods fail to effectively clone natural product BGCs of this nature, CAPTURE excels.
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