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How Scientists Are Tackling Brain Imaging s Replication Problem

REPUBLISHED WITH PERMISSION,  PSYCHOL SCI, DOI:10.1177/0956797620916786, 2020 When Maxwell Elliott’s latest research paper began making the rounds on Twitter last June, he wasn’t sure how he felt.  Elliott, a graduate student in clinical psychology in Ahmad Hariri’s lab at Duke University in Durham, North Carolina, studies functional magnetic resonance imaging (fMRI) and how it can be used to better understand neurological conditions such as dementia and autism.  He was excited that this “nitty-gritty” aspect of the field, as he describes it, was garnering a bit more attention, but the reason for the buzz disappointed him: A news outlet had picked up the story and run it with an overstated headline: “Duke University researchers say every brain activity study you’ve ever read is wrong.” 

NIMH » CV of Margaret L Westwater

NIMH » CV of Nicholas L Balderston

Torrisi, S, Gorka, AX, Gonzalez-Castillo, J, Balderston, NL, Grillon, C, & Ernst, M (2018). Extended amygdala connectivity changes during sustained shock anticipation. Translational Psychiatry. 8(33) 2017 Balderston, NL, Liu, J, Roberson-Nay, R, Ernst, M, & Grillon, C (2017). The relationship between dlPFC activity during unpredictable threat and CO2-induced panic symptoms. Translational Psychiatry, 7(12), 1266. Balderston NL, Hsiung A, Ernst M, Grillon C (2017) The effect of threat on right dlPFC activity during behavioral pattern separation. J Neurosci 37:0717–17. Balderston NL, Hsiung A, Liu J, Ernst M, Grillon C (2017) Reducing State Anxiety Using Working Memory Maintenance. J Vis Exp:1–11. Balderston NL, Hale E, Hsiung A, Torrisi S, Holroyd T, Carver FW, Coppola R, Ernst M, Grillon C (2017) Threat of shock increases excitability and connectivity of the intraparietal sulcus. Elife 6:1–27.

NIMH » Section on Functional Imaging Methods

Section on Functional Imaging Methods The section on Functional Imaging Methods is within the Laboratory of Brain and Cognition and the National Institute of Mental Health. Functional MRI is a technique that utilizes time series collection of rapidly-obtained magnetic resonance images that are sensitive to localized brain activation induced hemodynamic changes. The utility of Functional MRI (fMRI) has been increasing since it was discovered in 1991. The limits of the technique (spatial and temporal resolution, interpretability of the signal, and applications) are determined by imaging technology, experimental and processing methodology, and the variable and undetermined relationship between neuronal activity and hemodynamic changes.

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