Credit: The Wistar Institute
PHILADELPHIA and MELBOURNE, Australia (May. 17, 2021) A team of scientists from The Wistar Institute in Philadelphia and the Peter MacCallum Cancer Center in Melbourne, Australia, discovered a new checkpoint mechanism that fine-tunes gene transcription. As reported in a study published in
Cell, a component of the Integrator protein complex tethers the protein phosphatase 2A (PP2A) to the site of transcription allowing it to stop the activity of the RNA polymerase II enzyme (RNAPII). Disruption of this mechanism leads to unrestricted gene transcription and is implicated in cancer.
The study points to new viable opportunities for therapeutic intervention demonstrating the anti-cancer effect of a new combination treatment in preclinical models of solid and hematopoietic malignancies.
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New cellular atlas maps out healthy and cancerous breast tissue
WEHI researchers have documented the diversity of cells in the human breast, explaining the relationship between healthy breast cells and breast cancer cells.
The diversity of cells in the human breast has been
documented in a new ‘RNA atlas’.
The research, which relied on expertise spanning from breast cancer biology through to bioinformatics, measured gene expression in single cells taken from healthy women and cancerous breast tissue, including tissue carrying a faulty BRCA1 gene. This enabled the researchers to create an ‘RNA atlas’ that details the different cells found in these tissues.
The Directors 75 Add to collection
FINCH director on being a designer turned director, his work for Sony and Audi and the reason he loves directing so much
FINCH s Toby Pike is a multidisciplinary designer and director working across commercial, music and installation projects.
Through his award-winning career Toby has developed a truly unique, hyper-real aesthetic that merges film, technology, lighting, motion design and visual effects in a way that feels very human and emotionally engaging.
Toby has been fortunate to work alongside some of Australia’s top music talent such as Flume, Chet Faker (Nick Murphy), Pnau, Flight Facilities, and Rufus. Internationally, he has worked with Brian Eno, Karl Hyde & Warp Records. Commercially, he has worked with such brands as Nike, Coke, Tiger Beer, Qantas, Disney, Star Wars, Pepsico, Google, HP, Lexus and The New York Art Directors Club.
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IMAGE: A cell in yellow is shown dying by necroptosis, a process requiring the protein MLKL view more
Credit: WEHI Australia
A new molecular freeze frame technique has allowed WEHI researchers to see key steps in how the protein MLKL kills cells.
Small proteins called monobodies were used to freeze MLKL at different stages as it moved from a dormant to an activated state, a key process that enables an inflammatory form of cell death called necroptosis. The team were able to map how the three-dimensional structure of MLKL changed, revealing potential target sites that might be targets for drugs - a potential new approach to blocking necroptosis as a treatment for inflammatory diseases.
Multiphoton Microscopy Protocol Reveals Breast Cell Function, Behavior Inside Living Tissue | Research & Technology | Mar 2021 photonics.com - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from photonics.com Daily Mail and Mail on Sunday newspapers.