Scientists conduct interdisciplinary study on using nanoparticles to fight leukemia
Scientists from Scientific and Educational Center & Smart Materials and Biomedical Applications under the leadership of Kateryna Levada together with colleagues from Center for Immunology and Cellular Biotechnology of the Immanuel Kant Baltic Federal University conducted a joint interdisciplinary study on the development of a new method for treating leukemia using nanomaterials.
The scientists analyzed how magnetic nanoparticles can be manipulated in in vitro conditions to achieve a selective antitumor effect. The method is based on the combined action of nanoparticles and permanent magnetic fields on human tumor cells.
Leukemia (lymphoblastic leukemia) is the most common type of blood cancer in children and adolescents. This cancer affects the bone marrow and leads to the degradation of the human immune system. It accounts for 75-80% of acute leukemias, which also affect adults. Current methods of
Toxic pesticide turned into treatment against antibiotic-resistant bacteria
N-Aryl-C-nitroazoles are an important class of heterocyclic compounds. They are used as pesticides and fungicides. However, these substances could be toxic to humans and cause mutations. As they are not frequently used, there is little data about them in the medicinal chemistry literature. However, it has been suggested recently that the groups of compounds that are traditionally avoided can help to fight pathogenic bacteria. Yet, to reduce toxic effects, a great amount of work must be carried out at the molecular level, accurate optimization of the molecular environment of the nitro-heteroaromatic warhead .
Toxic Pesticide may Treat Antibiotic-resistant Bacteria by Angela Mohan on December 30, 2020 at 5:07 PM
N-Aryl-C-nitroazoles are heterocyclic compounds that are commonly used as pesticides and fungicides. They are toxic to humans and not used. Recently it has been suggested these agents could help fight pathogenic bacteria.
But a great amount of work must be carried out at the molecular level, accurate optimization of the molecular environment of the nitro-heteroaromatic warhead .
The validity of this approach was demonstrated in the early 2000s through the development of anti-tuberculosis drugs delamanid and pretomanid, currently approved for medical use. They act like prodrugs, that is, the substance itself is inactive, but acquires new properties when it enters the human body.
Scientists turn toxic pesticide into treatment against antibiotic-resistant bacteria phys.org - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from phys.org Daily Mail and Mail on Sunday newspapers.