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Toxic pesticide turned into treatment against antibiotic-resistant bacteria

Toxic pesticide turned into treatment against antibiotic-resistant bacteria N-Aryl-C-nitroazoles are an important class of heterocyclic compounds. They are used as pesticides and fungicides. However, these substances could be toxic to humans and cause mutations. As they are not frequently used, there is little data about them in the medicinal chemistry literature. However, it has been suggested recently that the groups of compounds that are traditionally avoided can help to fight pathogenic bacteria. Yet, to reduce toxic effects, a great amount of work must be carried out at the molecular level, accurate optimization of the molecular environment of the nitro-heteroaromatic warhead .

Sankt peterburgMikhail krasavinEmily hendersonResearch institute of phthisiopulmonologyL pasteur research institute of epidemiologyImmanuel kant baltic federal universityProfessor of the russian academy sciencesPetersburg state universityBaltic federal universityResearch instituteChemical scienceRussian academyImmanuel kant baltic federalMedicinal chemistryஎமிலி ஹென்டர்சன்ல் பாஸ்டர் ஆராய்ச்சி நிறுவனம் ஆஃப் தொற்றுநோய்

Toxic Pesticide may Treat Antibiotic-resistant Bacteria

Toxic Pesticide may Treat Antibiotic-resistant Bacteria by Angela Mohan on December 30, 2020 at 5:07 PM N-Aryl-C-nitroazoles are heterocyclic compounds that are commonly used as pesticides and fungicides. They are toxic to humans and not used. Recently it has been suggested these agents could help fight pathogenic bacteria. But a great amount of work must be carried out at the molecular level, accurate optimization of the molecular environment of the nitro-heteroaromatic warhead . The validity of this approach was demonstrated in the early 2000s through the development of anti-tuberculosis drugs delamanid and pretomanid, currently approved for medical use. They act like prodrugs, that is, the substance itself is inactive, but acquires new properties when it enters the human body.

Sankt peterburgMikhail krasavinResearch institute of phthisiopulmonologyL pasteur research institute of epidemiologyImmanuel kant baltic federal universityProfessor of the russian academy sciencesPetersburg state universityBaltic federal universityResearch instituteChemical scienceRussian academyImmanuel kant baltic federalல் பாஸ்டர் ஆராய்ச்சி நிறுவனம் ஆஃப் தொற்றுநோய்இம்மானுவேல் காந்த் பால்டிக் கூட்டாட்சியின் பல்கலைக்கழகம்ப்ரொஃபெஸர் ஆஃப் தி ரஷ்ய கலைக்கழகம் அறிவியல்பீட்டர்ஸ்பர்க் நிலை பல்கலைக்கழகம்

Scientists turn toxic pesticide into treatment against antibiotic-resistant bacteria

Scientists turn toxic pesticide into treatment against antibiotic-resistant bacteria
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Sankt peterburgMikhail krasavinSergey chuprunResearch institute of phthisiopulmonologyL pasteur research institute of epidemiologyImmanuel kant baltic federal universityProfessor of the russian academy sciencesPetersburg state universityPanel of pathogensBaltic federal universityResearch instituteChemical scienceRussian academyImmanuel kant baltic federalMutually isomericAntimycobacterial screening hit