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“Scalp cooling is currently the only treatment to combat ‘chemotherapy-induced alopecia’, yet little is known about its cytoprotective effect on human hair follicles,” said Dr Georgopoulos, who talks about the science behind scalp cooling with his University colleague Dr Andrew Collett in the video below.
Before now, he explained, the most common and obvious presumption to describe how scalp cooling worked was that as the scalp is cooled, the veins become constricted thereby reducing the amount of blood flow, meaning less of the chemotherapy drug enters the hair follicle.
“However, this is a really exciting discovery because our research now shows it is not as simple as that. We were able to measure how much chemotherapy drug goes into the cultured cells from hair follicles and what we have found is that cooling actually dramatically reduces the amount of chemotherapy drug being absorbed by the rapidly-diving cells of the hair follicle,” he added.
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VIDEO: Paxman Scalp Cooling Limited and the University of Huddersfield signed a five-year research and collaboration agreement covering the PAXMAN Scalp Cooling Research Centre (PSC), a multi-disciplinary research group based at. view more
Credit: University of Huddersfield and Paxman
GROUND-BREAKING research from the University of Huddersfield, announced ahead of World Cancer Day 2021, proves that scalp cooling physically protects hair follicles from chemotherapy drugs. It is the world s first piece of biological evidence that explains how scalp cooling actually works and the mechanism behind its protection of the hair follicle.
The study, entitled Cooling-mediated protection from chemotherapy drug-induced cytotoxicity in human keratinocytes by inhibition of cellular drug uptake , has been published in the peer-reviewed journal