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Date Time Secret genetic switch in zebrafish key to heart regeneration Scientists have discovered a critical new gene in zebrafish that helps them repair damaged heart muscle. Researchers at the Victor Chang Cardiac Research Institute (VCCRI) and UNSW Sydney have identified a genetic switch in zebrafish that turns on cells, allowing them to divide and multiply after a heart attack and resulting in the complete regeneration and healing of damaged heart muscle in these fish. It’s already known that zebrafish can heal their own hearts, but how they performed this incredible feat remained unknown until now. In research published this month in Science, the team drilled down into a critical gene known as Klf1 that previously had only been identified in red blood cells. For the first time they discovered it played a vital role in healing damaged hearts.

New south walesBob grahamOzren bogdanovicKazu kikuchiDaniel hesselsonDavid humphreysVictor chang cardiac research instituteBiophysics divisionGarvan institute of medical researchHead of the institute molecular cardiologySenior lecturerMolecular cardiologyGarvan instituteMedical researchConjoint senior lecturer dr kazu kikuchiAssociate professor ozren bogdanovic