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Share Synthetic biology offers a way to engineer cells to perform novel functions, such as glowing with fluorescent light when they detect a certain chemical. Usually, this is done by altering cells so they express genes that can be triggered by a certain input.   However, there is often a long lag time between an event such as detecting a molecule and the resulting output, because of the time required for cells to transcribe and translate the necessary genes. MIT synthetic biologists have now developed an alternative approach to designing such circuits, which relies exclusively on fast, reversible protein-protein interactions. This means that there’s no waiting for genes to be transcribed or translated into proteins, so circuits can be turned on much faster within seconds.

Bonnie bergerBrian teagueRon weissTristan beplerDeepak mishraNational science foundation graduate research fellowship programArtificial intelligence laboratoryDepartment of biological engineeringInstitute for collaborative biotechnologiesNational institutes of healthNational science foundationDepartment of biochemistryUniversity of wisconsinUs army research officeEnergy research fellowshipBiological engineering