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Regular aspirin use at or after age 70 was associated with significantly reduced risk of colorectal cancer (CRC), but only in those who were already taking aspirin before turning 70, according to pooled data from two large cohorts of U.S. health professionals.
After adjustment for other risk factors, regular use was associated with a hazard ratio (HR) of 0.80 (95% CI 0.72-0.90) compared with non-regular use, reported Andrew T. Chan, MD, MPH, of Harvard Medical School and Massachusetts General Hospital in Boston.
As shown in their study online in
JAMA Oncology, this inverse association was evident, however, only among individuals who initiated aspirin use before age 70 (HR 0.80, 95% CI 0.67-0.95). Commencing use at or after 70 had no significant association with a lower risk of CRC (HR 0.92, 95% CI 0.76-1.11).
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Regular aspirin use has clear benefits in reducing colorectal cancer incidence among middle-aged adults, but also comes with some risk, such as gastrointestinal bleeding. And when should adults start taking regular aspirin and for how long?
There is substantial evidence that a daily aspirin can reduce risk of colorectal cancer in adults up to age 70. But until now there was little evidence about whether older adults should start taking aspirin.
A team of scientists set out to study this question. They were led by Andrew T. Chan, a professor of medicine at Harvard Medical School and gastroenterologist and chief of the Clinical and Translational Epidemiology Unit at Massachusetts General Hospital (MGH). Their report appears in JAMA Oncology.
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BOSTON - Regular aspirin use has clear benefits in reducing colorectal cancer incidence among middle-aged adults, but also comes with some risk, such as gastrointestinal bleeding. And when should adults start taking regular aspirin and for how long?
There is substantial evidence that a daily aspirin can reduce risk of colorectal cancer in adults up to age 70. But until now there was little evidence about whether older adults should start taking aspirin.
A team of scientists set out to study this question. They were led by Andrew T. Chan MD, MPH, a gastroenterologist and chief of the Clinical and Translational Epidemiology Unit at Massachusetts General Hospital (MGH). Their report appears in
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