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HIV Leaders Merck and Gilead to Team Up on Potential Game-Changer

Published: Mar 15, 2021 By Alex Keown Smith Collection/Gado/Getty Images & Justin Sullivan/Getty Images  Two of the biggest drugmakers in the HIV space are teaming up on a combination therapy that has the potential to be a game-changer for patients diagnosed with the dangerous virus for which there is no known cure. This morning, Gilead announced they would pair Gilead’s investigational capsid inhibitor, lenacapavir, and Merck’s investigational nucleoside reverse transcriptase translocation inhibitor, islatravir, into a two-drug regimen. Islatravir and lenacapavir are both potentially first-in-class medicines in late-stage clinical trials, with significant clinical data generated to date. Both medicines have long half-lives and have demonstrated activity at low dosages in clinical studies, which support development as an investigational combination regimen with long-acting formulations, both oral and injectable, the companies announced this morning. The combi

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