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ONK Therapeutics Ltd, an innovative natural killer (NK) cell therapy company, today announced that it has entered into an exclusive global patent license agreement with Australia’s Walter and Eliza Hall Institute of Medical Research (WEHI) providing rights to CISH KO in the field of NK cells for the treatment of cancer.
“Deletion of CISH in NK cells leads to an improved metabolic profile, greatly enhances their proliferation, cytotoxicity, and persistence.
In-vivo models of cancer have shown that CISH KO NK cells are much more efficient in eliminating cancer cells, making such cells a very attractive prospect for future clinical development,” said Prof Michael O’Dwyer, CSO of ONK Therapeutics.
Cytokine Inducible SH2 containing protein (CIS; encoded by the gene CISH) is a potent checkpoint in NK cell-mediated tumor immunity CISH knockout (KO) NK cells have been shown to be more efficient
ONK Therapeutics Secures Exclusive Global License to Patent for CISH Knockout in NK Cells for the Treatment of Cancer, from Australia s WEHI pharmiweb.com - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from pharmiweb.com Daily Mail and Mail on Sunday newspapers.
Engineered Immune Cells Eliminate Brain Cancer in Mice
Researchers developed a new CAR T-cell therapy that targets specific growth factor receptors in glioblastoma to eliminate brain tumors.
Brooke Dulka, PhD
May 25, 2021
In Australia’s oldest medical research institute, researchers work to cure an aggressive brain cancer known as glioblastoma. The last decade has transformed the field of cancer research; blood cancers that were once death sentences now have treatment options. But glioblastoma remains a deadly enigma.
“I realized there was hardly any research happening in brain cancer, and applying immunotherapy there was the bold and ambitious plan we set for ourselves,” said immunologist Misty Jenkins, an associate professor at the Walter and Eliza Hall Institute of Medical Research in Melbourne, Australia. In a new study published in
May 25, 2021
New Fellows
The Australian inventor of 3D-printed bone substitutes is among a group of scientists being acknowledged today for their outstanding contributions to science.
Professor Hala Zreiqat and her team developed world-first techniques for 3D-printing strong, bio-compatible ceramic materials that can bond to and help repair bones. This is leading to the development of new orthopaedic implants, including the world’s first synthetic material for healing large areas of bone while supporting weight.
The Jordanian migrant who came to Australia in 1991 to pursue her dream of medical research is one of 22 scientists newly elected a Fellow of the Australian Academy of Science.