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Pursuing promising candidates for PAH
Endothelial cells and smooth muscle cells are dysfunctional in pulmonary arterial hypertension (PAH). Gu
et al. used transcriptomics and induced pluripotent stem cell–derived endothelial cells from patients with PAH to identify a tyrosine kinase inhibitor, tyrphostin-AG1296, that improved survival of cells. AG1296 activated bone morphogenetic protein receptor signaling and limited the proliferation of PAH smooth muscle cells, and its drug signature correlated with an anti-PAH gene signature. Treatment of a rat model of pulmonary hypertension reversed vascular remodeling and AG1296-induced regression of lesions in lung organ cultures ex vivo. Combining transcriptomics with functional cell assays could accelerate identification of drug candidates for PAH.
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Increasing demands for cancer medicines, falling cost of sequencing procedures, and a rise in demand for personalized medicines are key factors contributing to the high CAGR of the gene expression market during the forecast period.
The Global Gene Expression Market is expected to reach USD 6.78 billion by the year 2027, in terms of value at a CAGR of 8.1% over the forecast period. Gene expression promises to tap into a previously unexplored segment in the vast and burgeoning genetic engineering industry.
An increase in investments towards technological advancements and a rise in healthcare expenditure are estimated to shape the growth of the gene expression market. Drug discovery & development and increased demand for personalized medicine in chronic diseases, such as cancer, would be the most lucrative applications for gene expression analysis in the forecast period. Application of gene expression in clin
Global Gene Expression Market By Product And Services, By Capacity, By Application, And Segment Forecasts To 2027 - ResearchAndMarkets com
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