email article
A more gradual increase in oral osilodrostat (Isturisa) dosing was better tolerated among patients with Cushing s disease, compared with those who had more accelerated increases, a researcher reported.
Looking at outcomes from two phase III trials assessing osilodrostat, only 27% of patients had hypocortisolism-related adverse events if dosing was gradually increased every 3 weeks, said Maria Fleseriu, MD, of Oregon Health & Science University in Portland, in a presentation at the virtual meeting of the American Association of Clinical Endocrinology (AACE).
On the other hand, 51% of patients experienced a hypocortisolism-related adverse event if osilodrostat dose was increased to once every 2 weeks.
JAMA Heath Forum:
JAMA Health Forum has transitioned from an information channel to an international, peer-reviewed, online, open access journal that addresses health policy and strategies affecting medicine, health and health care. The journal publishes original research, evidence-based reports and opinion about national and global health policy; innovative approaches to health care delivery; and health care economics, access, quality, safety, equity and reform. Its distribution will be solely digital and all content will be freely available for anyone to read.
Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.
email article
A cocktail of two monoclonal antibodies against COVID-19, casirivimab and imdevimab, reduced hospitalization and death by 71% versus placebo in high-risk, non-hospitalized patients, a researcher said.
COVID-19 hospitalization or all-cause mortality was significantly reduced through day 29 among high-risk patients who were randomized to the intervention (HR 0.29, 95% CI 0.17-0.49), reported Julie Philley, MD, of the University of Texas Health Science Center in Tyler.
Moreover, treatment with the intravenous monoclonal antibody combination was associated with 4 fewer days of symptom duration compared with placebo.
Casirivimab and imdevimab received emergency use authorization from the FDA in November, which was granted on the basis of phase I/II trial results in non-hospitalized adults with mild or moderate COVID-19. President Trump was treated with this therapy when he had COVID-19 in October 2020.
Josh Andersen/Oregon Health & Science University
hide caption
toggle caption Josh Andersen/Oregon Health & Science University
Carlene Knight, 54, is one of the first patients in a landmark study designed to try to restore vision in those who have a rare genetic disease that causes blindness. Josh Andersen/Oregon Health & Science University
Carlene Knight would love to do things that most people take for granted, such as read books, drive a car, ride a bike, gaze at animals in a zoo and watch movies. She also longs to see expressions on people s faces. To be able to see my granddaughter especially my granddaughter s face, said Knight, 54, who lives outside Portland, Ore. It would be huge.